ZKSCAN3 Antibody, Biotin conjugated

Code CSB-PA861122LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZKSCAN3 Polyclonal antibody
Uniprot No.
Target Names
ZKSCAN3
Alternative Names
dJ874C20.1 antibody; mszf35 antibody; SCAN-KRAB-zinc finger protein antibody; Skz1 antibody; Zf47 antibody; Zfp-47 antibody; ZFP306 antibody; Zfp307 antibody; Zfp47 antibody; Zinc finger and SCAN domain containing protein 13 antibody; Zinc finger and SCAN domain-containing protein 13 antibody; Zinc finger protein 306 antibody; Zinc finger protein 306; isoform CRA_a antibody; Zinc finger protein 307 antibody; Zinc finger protein 309 antibody; Zinc finger protein 47 homolog antibody; Zinc finger protein with KRAB and SCAN domains 3 antibody; Zinc finger protein with KRAB and SCAN domains 3 antibody; Zinc finger protein zfp47 antibody; Zinc finger with KRAB and SCAN domains 3 antibody; ZKSC3_HUMAN antibody; ZKSCAN3 antibody; ZNF309 antibody; ZSCAN13 antibody; ZSCAN35 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger protein with KRAB and SCAN domains 3 protein (8-275AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
Gene References into Functions
  1. These results suggest that ZKSCAN3 plays an important role in bladder cancer outgrowth PMID: 27447553
  2. ZKSCAN3 appears to promote colorectal tumor progression and invasion. ZKSCAN3 may facilitate hepatic metastasis of CRC associated with CEA particularly in cases with CEA-producing tumor PMID: 27127149
  3. Suggest ZKSCAN3 as an autophagy master switch regulating the expression of a transcriptional network of genes integral to autophagy and lysosome biogenesis/function. PMID: 23434374
  4. ZKSCAN3 induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation and contribute to disease pathogenesis. PMID: 21057542
  5. ZKSCAN3 adds to an expanding set of encoded products contributing to the progression of colorectal cancer PMID: 18519692
  6. ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4 and VEGF PMID: 18940803

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Subcellular Location
Nucleus. Cytoplasm. Note=Mainly localizes in the nucleus. Under starvation conditions translocates to the cytoplasm, allowing expression of target genes involved in autophagy and lysosome biogenesis/function.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Database Links

HGNC: 13853

OMIM: 612791

KEGG: hsa:80317

STRING: 9606.ENSP00000252211

UniGene: Hs.380930

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